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33

NCCN Guidelines for Patients

®

:

Breast Cancer – Metastatic (STAGE IV), Version 2.2017

3

Treatment guide

Hormone receptor–negative cancers

Bevacizumab is not used often to treat breast cancer.

It doesn’t extend life or improve quality of life. It may

help to slow down cancer growth.

Bevacizumab is given by infusion. It takes about

90 minutes to get the first dose and 30 minutes for

later doses. Bevacizumab is given every two weeks

followed by a two-week rest period.

Common side effects of bevacizumab are high blood

pressure, diarrhea, and feeling tired and weak. You

might also have nosebleeds, shortness of breath,

nausea, and vomiting. Rare but serious effects

include stroke, heart attack, kidney damage, holes in

the intestine, and bleeding within the body.

Guide 5. Targeted therapy

Type

Generic name

Brand name How they work

HER2 antibodies

Pertuzumab

Perjeta

®

Prevent the start of key signals for

cancer cell growth

Trastuzumab

Herceptin

®

HER2 conjugates Ado-trastuzumab emtansine Kadcyla

®

Deliver cell-specific chemotherapy

HER2 inhibitors

Lapatinib ditosylate

Tykerb

®

Stop key signals for cancer cell growth

VEGF antibodies Bevacizumab

Avastin

®

Prevent the start of key signals for

endothelial cell growth

Figure 11

HER2 antibodies and

inhibitors

Antibodies are Y-shaped

proteins that are made by your

body to help fight illness. HER2

antibodies are human-made

antibodies. They attach to the

HER2 on the outside of the cell,

which prevents growth signals

from starting. HER2 inhibitors

attach to HER2 inside the cell and

stop growth signals.

Copyright © 2016 National Comprehensive Cancer Network

®

(NCCN

®

).

www.nccn.org

HER2

antibody

inhibitor

stops

growth

signals

cancer cell