NCCN Guidelines for Patients
Stomach Cancer, Version 1.2016
Preparing for treatment
In normal stomach cells, there are two copies of the
gene that makes HER2. HER2 is a surface receptor
found in the membrane of cells.
See Figure 8
activated, it sends signals within the cell telling it to
grow and divide.
Some stomach cancers have cells with more than
two copies of the
gene, thus causing too many
HER2 receptors to be made. Other stomach cancers
have cells with only two
gene copies, but still
too many HER2 receptors are made. With too many
HER2 receptors, the cancer cells grow and divide
fast. However, there is treatment that targets HER2.
Based on current research, HER2 testing is advised
for metastatic cancer. Due to high costs and the
side effects of treatment, it is very important to
have tests that correctly show HER2 status. IHC
hemistry) is the test used to measure
the amount of HER2 receptors. Another test of HER2
status is ISH (
ybridization). ISH counts the
number of copies of the
Some stomach cancers consist of
cells with many HER2 receptors.
HER2 is one type of surface
receptor that triggers growth
signals within cells. It is important
to test for HER2 status if the
cancer has spread to distant sites
(M1 stage). Testing will allow your
doctor to plan the best treatment.
Copyright © 2016 National Comprehensive Cancer Network® (NCCN®).www.nccn.org