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NCCN Guidelines for Patients



Waldenström’s Macroglobulinemia, Version 1.2017

Figure 2

Lymph vessels and nodes

Throughout your body, including

your lungs, is a network of

vessels that transport lymph to

the bloodstream. Lymph is a clear

fluid that contains germ-fighting

blood cells. As lymph travels in

vessels, it passes through lymph

nodes, which remove germs from



Waldenström’s macroglobulinemia The lymphatic system


Lymph cells are called lymphocytes. Two main

lymphocytes are:




are a type of white blood cell made

in the bone marrow. Most B cells turn into a

plasma cell in response to germs. Antibodies,

also called immunoglobulins, are proteins made

by plasma cells (a type of white blood cell) that

helps the body fight infections.




are a type of white blood cell made in

the bone marrow that moves to the thymus.

T-cells attacks germs, help the B-cell response,

and make cytokines. Cytokines are substances

made in the body that boost or activate the

body’s disease-fighting ability. Cytokines can

also be made in a lab.

Lymphocytes are made in bone marrow and then

moved by blood to the lymphatic system. Other

parts of your body that have many lymphocytes

are included in the lymphatic system. In children,

the thymus stores T-cells until they are able to fight

germs. Germs in blood are filtered and destroyed

by lymphocytes within your spleen. Your tonsils kill

germs in lymph that enter through your mouth and

nose. There are also small clumps of lymphatic

tissue in your thyroid, breasts, lungs, liver, eyes, skin,

and gut.

Figure 1

Lymphatic system

The lymphatic system ills germs

in th body and collects and

transp rt lymph to the


Illustration Copyright © 2016 Nucleus Medical Media, All rights reserved.