NCCN Guidelines for Patients
Waldenström’s Macroglobulinemia, Version 1.2017
Below are a few common targeted therapies for WM.
Your doctor will offer treatment options based on your
health and disease status. This includes your current
symptoms, IgM level, and extent of cancer in your
Rituximab is a monoclonal antibody that attaches
to an antigen called CD20. It is normally found on B
See Figure 5.
The attachment tells the cell
to die. Cell death is called apoptosis. Monoclonal
antibodies are man-made antibodies that mark cells
for destruction by your immune system. Rituximab
can be given alone, with chemotherapy, or another
cancer drug to treat WM. These drugs include
cyclophosphamide, bendamustine, bortezomib,
carfilzomib, fludarabine, or cladribine.
Rituximab is a liquid that is slowly injected into a
vein. It can take hours to receive the full dose. Your
doctor may give you medication beforehand to
prevent an allergic reaction. He or she will decide on
the dose (amount given), how long it is given, and
how often you get this drug.
Common side effects of rituximab are:
Extreme tiredness (fatigue)
Low blood cell counts
Rituximab attaches to
Rituximab attaches to the
CD20 protein on a B-cell.
Derivative work of Rituximab Binding to CD20 on a B Cell Surface by NIAID available atcommons.wikimedia.org/wiki/
(6830897205).jpg under a Creative Commons Attribution 2.0 Generic license.