National Comprehensive Cancer Network



About The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®)
Development and Update of the NCCN Guidelines
Recent Updates to NCCN Guidelines®
NCCN Guidelines Panels-Meeting Schedule
NCCN Categories of Evidence and Consensus
NCCN Categories of Preference
NCCN Guidelines® Steering Committee
Transparency: Process and Recommendations
Submission Request to the NCCN Guidelines Panels
Submission Request History
NCCN Compendium®
About the NCCN Compendium®
NCCN Compendium® Chapters By Disease
Subscribe to the NCCN Compendium
No Longer Recommended Uses
NCCN Framework for Resource Stratification of NCCN Guidelines
(NCCN Framework™)

NCCN Guidelines® & Clinical Resources

NCCN Categories of Evidence and Consensus

  • Category 1: Based upon high-level evidence, there is uniform NCCN consensus that the intervention is appropriate.
  • Category 2A: Based upon lower-level evidence, there is uniform NCCN consensus that the intervention is appropriate.
  • Category 2B: Based upon lower-level evidence, there is NCCN consensus that the intervention is appropriate.
  • Category 3: Based upon any level of evidence, there is major NCCN disagreement that the intervention is appropriate.

All recommendations are category 2A unless otherwise noted.

NCCN Categories of Preference

  • Preferred intervention: Interventions that are based on superior efficacy, safety, and evidence; and, when appropriate, affordability
  • Other recommended intervention: Other interventions that may be somewhat less efficacious, more toxic, or based on less mature data; or significantly less affordable for similar outcomes
  • Useful in certain circumstances: Other interventions that may be used for selected patient populations (defined with recommendation)

All recommendations in the NCCN Guidelines are considered appropriate.

For more information on the NCCN Categories of Preference click here.