National Comprehensive Cancer Network

Clinical Recommendations

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NCCN Clinical Practice Guidelines in Oncology™

The NCCN Clinical Practice Guidelines in Oncology™ – the recognized standard for clinical policy in oncology – are the most comprehensive and most frequently updated clinical practice guidelines available in any area of Medicine. Covering 97 percent of all patients with cancer and updated on a continual basis, the NCCN Guidelines are developed through an explicit review of the evidence integrated with expert medical judgment by multidisciplinary panels from NCCN Member Institutions. Treatment recommendations are specific and are implemented through performance measurement. NCCN Guidelines Panels address cancer detection, prevention and risk reduction, workup and diagnosis, treatment and supportive care.

Each individual NCCN Guideline is posted with its latest update date and version number.

The NCCN Clinical Practice Guidelines in Oncology™ are copyrighted by the NCCN. All rights reserved. NCCN Guidelines and illustrations may not be reproduced in any form for any purpose without the express written permission of the NCCN. Permission Request Section

View the NCCN Guideline Panel Members individual disclosures

Guidelines for Treatment of Cancer by Site

• Acute Myeloid Leukemia
• Bladder Cancer
  • Bladder Cancer
  • Upper Tract Tumors
  • Urothelial Carcinoma of the Prostate
• Bone Cancer
  • Chondrosarcoma
  • Ewing’s Sarcoma
  • Osteosarcoma
• Breast Cancer
  • Noninvasive
  • Invasive
  • Phyllodes Tumor
  • Paget's Disease
  • Breast Cancer During Pregnancy
• Central Nervous System Cancers
  • Adult Low-Grade Infiltrative Supratentorial Astrocytoma/Oligodendroglioma
  • Adult Intracranial Ependymoma
  • Anaplastic Astrocytoma/Anaplastic Oligodendroglioma/Glioblastoma Multiforme
  • Limited (1-3) Metastatic Lesions
  • Multiple (>3) Metastatic Lesions
  • Carcinomatous Lymphomatous Meningitis
  • Nonimmunosuppressed Primary CNS Lymphoma
  • Metastatic Spine Tumors
• Cervical Cancer
• Chronic Myelogenous Leukemia
• Colon/Rectal Cancer
  • Colon Cancer
  • Rectal Cancer
  • Anal Carcinoma
• Esophageal Cancer
• Gastric Cancer
• Head and Neck Cancers
  • Ethmoid Sinus Tumors
  • Maxillary Sinus Tumors
  • Salivary Gland Tumors
  • Cancer of the Lip
  • Cancer of the Oral Cavity
  • Cancer of the Oropharynx
  • Cancer of the Hypopharynx
  • Occult Primary
  • Cancer of the Glottic Larynx
  • Cancer of the Supraglottic Larynx
  • Cancer of the Nasopharynx
  • Advanced Head and Neck Cancer
• Hepatobiliary Cancers
  • Hepatocellular Carcinoma
  • Gallbladder Cancer
  • Intrahepatic Cholangiocarcinoma
  • Extrahepatic Cholangiocarcinoma
• Hodgkin Disease/Lymphoma
• Kidney Cancer
• Melanoma
• Multiple Myeloma
• Multiple Myeloma
• Systemic Light Chain Amyloidosis
• Waldenström’s Macroglobulinemia
• Myelodysplastic Syndromes
• Neuroendocrine Tumors
• Carcinoid Tumors
• Islet Cell Tumors (Pancreatic Endocrine Tumors)
• Neuroendocrine Unknown Primary
• Adrenal Gland Tumors
• Pheochromocytoma
• Poorly Differentiated (High Grade or Anaplastic)/Small Cell
• Multiple Endocrine Neoplasia, Type 1
• Multiple Endocrine Neoplasia, Type 2
• Non-Hodgkin’s Lymphomas
  • Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
  • Follicular Lymphoma
  • Marginal Zone Lymphoma
  • Mantle Cell Lymphoma
  • Diffuse Large B-Cell Lymphoma
  • Burkitt's Lymphoma
  • Lymphoblastic Lymphoma
  • AIDS-Related B-Cell Lymphoma
  • Peripheral T-Cell Lymphoma
  • Mycosis Fungoides/Sézary Syndrome
  • Primary Cutaneous B-Cell Lymphoma
• Non-Melanoma Skin Cancers
  • Basal and Squamous Cell Skin Cancers
  • Dermatofibrosarcoma Protuberans
  • Merkel Cell Carcinoma
• Non-Small Cell Lung Cancer
• Occult Primary
• Ovarian Cancer
• Epithelial Ovarian Cancer
• Borderline Epithelial Ovarian Cancer (Low Malignant Potential)
• Less Common Ovarian Histologies
• Pancreatic Adenocarcinoma
• Prostate Cancer
• Small Cell Lung Cancer
• Small Cell Lung Cancer
• Lung Neuroendocrine Tumors
• Soft Tissue Sarcoma
  • Extremity
  • Retroperitoneal/Intra-Abdominal
  • Gastrointestinal Stromal Tumors (GIST)
  • Desmoid tumors
• Testicular Cancer
• Thymic Malignancies
• Thyroid Carcinoma
• Nodule Evaluation
• Papillary Carcinoma
• Follicular Carcinoma
• Hürthle Cell Neoplasm
• Medullary Carcinoma
• Anaplastic Carcinoma
• Uterine Neoplasms
  • Endometrial Cancer
  • Uterine Sarcoma

Guidelines for Detection, Prevention, & Risk Reduction

• Breast Cancer Risk Reduction
• Breast Cancer Screening and Diagnosis
• Cervical Cancer Screening
• Colorectal Cancer Screening
• Genetic/Familial High-Risk Assessment: Breast and Ovarian
• Breast and/or Ovarian Genetic Assessment
• Hereditary Breast and/or Ovarian Cancer
• Li-Fraumeni Syndrome
• Cowden Syndrome

Guidelines for Supportive Care

• Adult Cancer Pain
• Antiemesis
• Cancer- and Chemotherapy-Induced Anemia
• Cancer-Related Fatigue
• Distress Management
• Myeloid Growth Factors
• Palliative Care
• Prevention and Treatment of Cancer-Related Infections
• Senior Adult Oncology
• Venous Thromboembolic Disease

Disclaimer

These guidelines are a statement of evidence and consensus of the authors regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these guidelines is expected to use independent medical judgment in the context of individual clinical circumstances to determine any patient’s care or treatment. The National Comprehensive Cancer Network makes no representations or warranties of any kind regarding their content, use or application and disclaims any responsibility for their application or use in any way. These guidelines are copyrighted by National Comprehensive Cancer Network. All rights reserved. These guidelines and the illustrations herein may not be reproduced in any form without the express written permission of NCCN. ©2008/2009.

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