The NCCN Informed Consent Language (ICL) database is a comprehensive resource to assist researchers and clinical operations personnel with writing and amending informed consents for study participants. It currently contains more than 2,200 standardized lay language descriptions of risks and events associated with clinical research. The database content was developed through collaboration with two NCCN Member Institutions, namely, Dana-Farber Cancer Institute and The University of Texas MD Anderson Cancer Center. Both institutions' IRB groups routinely review, approve, and update the standardized language to ensure consistency and accuracy. NCCN is committed to supporting initiatives to improve clinical research processes and plans to expand the database to include language for drugs and medical procedures.