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National Comprehensive Cancer Network

About NCCN

Researchers Receive Grants from NCCN Oncology Research Program Funded Through GlaxoSmithKline

The NCCN Oncology Research Program received $4 million in research funding from GlaxoSmithKline to support research at NCCN Member Institutions in order to evaluate the effectiveness of ofatumumab (Arzerra®, GlaxoSmithKline) in hematologic malignancies and pazopanib (Votrient™, GlaxoSmithKline) in the treatment of solid tumors.

FORT WASHINGTON, PA — The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program (ORP) recently awarded research grants to investigators following a review of proposals submitted in response to the NCCN Ofatumumab Request for Proposals and the NCCN Pazopanib Request for Proposals. These grants were made possible through general research support of $4 million from GlaxoSmithKline.

NCCN is pleased to announce that we will be funding five new ofatumumab research studies and seven pazopanib research studies in 2011, in addition to more than 50 active clinical and correlative trials that we are already supporting, commented Diane Paul, MS, RN, Vice President, ORP, NCCN. Research grants enable NCCN and our member institutions to work with industry to help develop and bring scientific discoveries to market for the benefit of all patients. We are grateful for the opportunity to work with GlaxoSmithKline to make important strides in research possible.

The U.S. Food and Drug Administration (FDA) granted approval of ofatumumab for the treatment of patients with chronic lymphocytic leukemia (CLL) refractory to fludarabine and alemtuzumab. In addition to CLL, the clinical trials at NCCN Member Institutions supported by the grant will further evaluate the therapy`s effect in various lymphomas, including follicular, mantle cell, diffuse large B-cell, and non-Hodgkin`s lymphomas.

The following proposals for ofatumumab have been awarded funding:

  • Jennifer Brown, MD, PhD,Dana-Farber Cancer Institute, Ofatumumab-High Dose Methylprednisolone Followed by Ofatumumab-Alemtuzumab for the Treatment of 17p Deletion Chronic-Lymphocytic Leukemia.
  • Alessandra Ferrajoli, MD, The University of Texas MD Anderson Cancer Center, Phase II Study of Ofatumumab as Front-Line Treatment in Elderly, Unfit Patients with Chronic Lymphocytic Leukemia (CLL).
  • Francisco Hernandez-llizaliturri, MD, Roswell Park Cancer Institute, Ofatumumab in Combination with High Dose Cytarabine Chemoimmunotherapy for Patients with Newly Diagnosed Mantle Cell Lymphoma (MCL).
  • Shuo Ma, MD, PhD, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Correlative Studies in Conjunction with A Phase 2 Trial of Alemtuzumab-Ofatumumab Combination in Previously Untreated Symptomatic Chronic Lymphocytic Leukemia (CLL).
  • Taimur Sher, MD, Roswell Park Cancer Institute, A Multicenter Phase II Study of Ofatumumab in Combination with Bortezomib in Previously Untreated Patients with Waldenström Macroglobulinemia.


Pazopanib is currently approved by the FDA to treat patients with advanced renal cell carcinoma. The research grant to NCCN will evaluate the effectiveness of pazopanib in solid tumors, including sarcoma, thyroid, and neuroendocrine cancers.

The following proposals for pazopanib have been awarded funding:


The awardees responded to Requests for Proposals issued by the NCCN ORP to the 21 NCCN Member Institutions. Submissions were peer reviewed by the NCCN Ofatumumab Scientific Review Committee and the NCCN Pazopanib Scientific Review Committee. The awardees were selected based on several key components, including scientific merit, existing data, and the types of studies necessary to further evaluate the activity of the drugs.

The NCCN Oncology Research Program (ORP) draws on the expertise of investigators at NCCN Member Institutions to facilitate all phases of clinical research. This research is made possible by collaborations with pharmaceutical and biotechnology companies in order to advance therapeutic options for patients with cancer. The NCCN ORP will utilize the grant from GlaxoSmithKline to support investigator-initiated clinical and correlative studies at its NCCN Member Institutions for ofatumumab and pazopanib. To date, this successful research model has received more than $34 million in research grants and provided 87 investigators with funding for clinical and correlative trials that have produced numerous publications in peer-reviewed journals.

About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of 30 leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, efficient, and accessible cancer care so patients can live better lives. Through the leadership and expertise of clinical professionals at NCCN Member Institutions, NCCN develops resources that present valuable information to the numerous stakeholders in the health care delivery system. By defining and advancing high-quality cancer care, NCCN promotes the importance of continuous quality improvement and recognizes the significance of creating clinical practice guidelines appropriate for use by patients, clinicians, and other health care decision-makers around the world.

The NCCN Member Institutions are:

  • Abramson Cancer Center at the University of Pennsylvania
  • Fred & Pamela Buffett Cancer Center
  • Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute
  • City of Hope National Medical Center
  • Dana-Farber/Brigham and Women's Cancer Center | Massachusetts General Hospital Cancer Center
  • Duke Cancer Institute
  • Fox Chase Cancer Center
  • Huntsman Cancer Institute at the University of Utah
  • Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance
  • The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University
  • Mayo Clinic Cancer Center
  • Memorial Sloan Kettering Cancer Center
  • Moffitt Cancer Center
  • The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute
  • O'Neal Comprehensive Cancer Center at UAB
  • Roswell Park Comprehensive Cancer Center
  • Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine
  • St. Jude Children's Research Hospital/The University of Tennessee Health Science Center
  • Stanford Cancer Institute
  • UC San Diego Moores Cancer Center
  • UCLA Jonsson Comprehensive Cancer Center
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • University of Colorado Cancer Center
  • University of Michigan Rogel Cancer Center
  • The University of Texas MD Anderson Cancer Center
  • University of Wisconsin Carbone Cancer Center
  • UT Southwestern Simmons Comprehensive Cancer Center
  • Vanderbilt-Ingram Cancer Center
  • Yale Cancer Center/Smilow Cancer Hospital