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NCCN Receives $2-Million Funding Commitment from ImmunoGen, Inc. to Study Mirvetuximab Soravtansine for Folate Receptor Alpha-Positive Cancers

The NCCN Oncology Research Program (ORP) has received a $2-million grant from ImmunoGen, Inc. to facilitate preclinical and clinical research with mirvetuximab soravtansine for folate receptor alpha-positive cancers at NCCN Member Institutions and their affiliate community hospitals. 

FORT WASHINGTON, PA — The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program (ORP) has been awarded a $2-million grant from ImmunoGen, Inc. to support the advancement of scientific knowledge related to mirvetuximab soravtansine (IMGN853), a potential new treatment for ovarian and other folate receptor alpha (FRα)-positive cancers.

“NCCN ORP values our collaboration with ImmunoGen on this significant research initiative,” said Diane E. Paul, MS, RN, Vice President, NCCN ORP. “This grant and the resulting research will provide investigators from NCCN Member Institutions the opportunity to advance medical research that may translate into improvements in survival and quality of life for patients with cancer.”

According to ImmunoGen, mirvetuximab soravtansine (IMGN853) is a potential new treatment for ovarian, endometrial, breast, and other cancers that highly express FRα. An antibody-drug conjugate (ADC), it comprises an ImmunoGen FRα-targeting antibody attached to the company's potent tubulin-acting agent, DM4. The antibody serves to target the compound specifically to cancer cells expressing FRα, and the DM4 serves to kill these cells.

The first phase of the program will involve the establishment of an NCCN Mirvetuximab Soravtansine Request for Proposals Team, comprising relevant experts from NCCN Member Institutions, to review the existing data and define the study areas appropriate to enhance insight into the potential role of mirvetuximab soravtansine in the treatment of FRα-positive cancers.

The NCCN ORP draws on the expertise of investigators at NCCN Member Institutions and the NCCN Affiliate Research Consortium (ARC) to facilitate all phases of clinical research. This research is made possible by collaborations with pharmaceutical and biotechnology companies in order to advance therapeutic options for patients with cancer. The NCCN ORP will utilize the grant from ImmunoGen, Inc. to support investigator-initiated preclinical, clinical, and correlative studies of mirvetuximab soravtansine at NCCN Member Institutions and their affiliate community hospitals. To date, this research model has received more than $54 million in research grants and supported 125 studies that have produced a number of publications in peer-reviewed journals.

ImmunoGen, Inc. is a biotechnology company focused on the development of targeted anticancer therapeutics. The company’s ADC technology uses tumor-targeting antibodies to deliver an ImmunoGen cell-killing agent specifically to cancer cells. The company utilizes its ADC technology with its antibodies to create ImmunoGen product candidates and also out-licenses limited rights to use its technology to other companies. Roche's Kadcyla® is the first marketed product with ImmunoGen's ADC technology. More information about the company can be found at www.immunogen.com.

To learn more about the NCCN ORP, ARC, and ongoing clinical trials, visit NCCN.org.

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About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network® (NCCN®), a not-for-profit alliance of 27 of the world's leading cancer centers, is dedicated to improving the quality and effectiveness of care provided to patients with cancer. Through the leadership and expertise of clinical professionals at NCCN Member Institutions, NCCN develops resources that present valuable information to the numerous stakeholders in the health care delivery system. As the arbiter of high-quality cancer care, NCCN promotes the importance of continuous quality improvement and recognizes the significance of creating clinical practice guidelines appropriate for use by patients, clinicians, and other health care decision-makers. The primary goal of all NCCN initiatives is to improve the quality, effectiveness, and efficiency of oncology practice so patients can live better lives. For more information, visit NCCN.org.

The NCCN Member Institutions are:

  • Fred & Pamela Buffett Cancer Center
  • Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute
  • City of Hope Comprehensive Cancer Center
  • Dana-Farber/Brigham and Women's Cancer Center | Massachusetts General Hospital Cancer Center
  • Duke Cancer Institute
  • Fox Chase Cancer Center
  • Huntsman Cancer Institute at the University of Utah
  • Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance
  • The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University
  • Mayo Clinic Cancer Center
  • Memorial Sloan Kettering Cancer Center
  • Moffitt Cancer Center
  • The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute
  • Roswell Park Cancer Institute
  • Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine
  • St. Jude Children's Research Hospital/The University of Tennessee Health Science Center
  • Stanford Cancer Institute
  • University of Alabama at Birmingham Comprehensive Cancer Center
  • UC San Diego Moores Cancer Center
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • University of Colorado Cancer Center
  • University of Michigan Comprehensive Cancer Center
  • The University of Texas MD Anderson Cancer Center
  • University of Wisconsin Carbone Cancer Center
  • Vanderbilt-Ingram Cancer Center
  • Yale Cancer Center/Smilow Cancer Hospital