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National Comprehensive Cancer Network

About The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®)
Development and Update of the NCCN Guidelines
Recent Updates to NCCN Guidelines®
NCCN Guidelines Panels-Meeting Schedule
NCCN Categories of Evidence and Consensus
NCCN Categories of Preference
NCCN Guidelines® Steering Committee
Transparency: Process and Recommendations
Submission Request to the NCCN Guidelines Panels
Submission Request History
NCCN Compendium®
About the NCCN Compendium®
Subscribe to the NCCN Compendium
No Longer Recommended Uses
NCCN Compendium User Guide
NCCN Framework for Resource Stratification of NCCN Guidelines
(NCCN Framework™)

NCCN Guidelines® & Clinical Resources

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) with NCCN Evidence Blocks™

NCCN Evidence Blocks™ are intended as a visual representation of five key measures that provide important information about specific recommendations contained within the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®).

  • Efficacy of Regimen/Agent
  • Safety of Regimen/Agent
  • Quality of Evidence
  • Consistency of Evidence
  • Affordability of Regimen/Agent
NCCN Evidence Blocks Categories and Definitions

The goal is to provide the health care provider and the patient information to make informed choices when selecting systemic therapies based upon measures related to treatment, supporting data, and cost. These measures may be used to understand the clinical and scientific rationale for specific recommendations and estimates of the economic impact of the recommendations. These measures may also be used to educate providers and patients, and to be a starting point for shared decision-making considering the patient’s own value system.

With the wide range of evidence-based potentially appropriate therapies, clinicians and patients must choose the one treatment that is most appropriate for the individual taking into account what matters most to the patient. For more than 20 years, the National Comprehensive Cancer Network® (NCCN®) has developed and published the NCCN Guidelines® based on critical analysis of the evidence by multidisciplinary expert clinicians and reaching consensus on which interventions constitute appropriate care.

As sub-specialists, panel members have the capacity to track and incorporate disease-specific data that has developed over the past several decades. In a rapidly evolving field like oncology, thousands of new publications are released each year adding to the existing body of knowledge and resulting in improvement in outcomes. Experts are able to integrate new findings with existing information to determine what the evolving standard of care should be for a given disease state. Implicit in the evaluation of each treatment is the efficacy and expected associated toxicities, as well as the quality, quantity, and consistency of the evidence supporting the recommendation. The NCCN Evidence Blocks™ will make the panels’ assessments of these parameters more transparent to the users of the NCCN Guidelines.

NCCN Evidence Blocks™ Development ▾

Using the NCCN Evidence Blocks™ ▾

NCCN Evidence Blocks™ Categories ▾

NCCN Evidence Blocks™ FAQ

NCCN Evidence Blocks™ User Guide

Learn more about the NCCN Evidence Blocks™:


NCCN Video Press Conference Recording

View the Press Release and Press Conference Recording
(October 2015)

NCCN Video Value Initiative

View The NCCN Value Initiative: Using NCCN Evidence Blocks™ in Clinical Decisions Recorded Presentation with a review of NCCN Guidelines with Evidence Blocks™ for Chronic Myelogenous Leukemia
(October 2015)

NCCN Video Value Initiative

View The NCCN Value Initiative: Using NCCN Evidence Blocks™ in Clinical Decisions Recorded Presentation with a review of NCCN Guidelines with Evidence Blocks™ for Renal Cell Carcinoma
(March 2016)


NCCN Evidence Blocks™ are available for the following:

NCCN Evidence Blocks™ will be published initially for systemic therapies in NCCN Guidelines with additional cancer types to come.

NCCN Evidence Blocks™ are copyrighted by NCCN. All rights reserved. NCCN Content may not be reproduced in any form for any purpose without the express written permission of NCCN. Permissions Requests Section