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Acute Lymphoblastic Leukemia Acute Myeloid Leukemia Ampullary Adenocarcinoma Anal Carcinoma Basal Cell Skin Cancer B-Cell Lymphomas Biliary Tract Cancers Bladder Cancer Bone Cancer Breast Cancer Castleman Disease Central Nervous System Cancers Cervical Cancer Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Chronic Myeloid Leukemia Colon Cancer Dermatofibrosarcoma Protuberans Esophageal and Esophagogastric Junction Cancers Gastric Cancer Gastrointestinal Stromal Tumors Gestational Trophoblastic Neoplasia Hairy Cell Leukemia Head and Neck Cancers

Hepatobiliary Cancers Hepatocellular Carcinoma Histiocytic Neoplasms Hodgkin Lymphoma Kaposi Sarcoma Kidney Cancer Melanoma: Cutaneous Melanoma: Uveal Merkel Cell Carcinoma Mesothelioma: Peritoneal Mesothelioma: Pleural Multiple Myeloma Myelodysplastic Syndromes Myeloid/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Gene Fusions Myeloproliferative Neoplasms Neuroblastoma Neuroendocrine and Adrenal Tumors Non-Small Cell Lung Cancer Occult Primary Ovarian Cancer/Fallopian Tube Cancer/Primary Peritoneal Cancer Pancreatic Adenocarcinoma Pediatric Acute Lymphoblastic Leukemia Pediatric Aggressive Mature B-Cell Lymphomas

Pediatric Central Nervous System Cancers Pediatric Hodgkin Lymphoma Penile Cancer Primary Cutaneous Lymphomas Prostate Cancer Rectal Cancer Small Bowel Adenocarcinoma Small Cell Lung Cancer Soft Tissue Sarcoma Squamous Cell Skin Cancer Systemic Light Chain Amyloidosis Systemic Mastocytosis T-Cell Lymphomas Testicular Cancer Thymomas and Thymic Carcinomas Thyroid Carcinoma Uterine Neoplasms Vaginal Cancer Vulvar Cancer Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma Wilms Tumor (Nephroblastoma)

Breast Cancer Risk Reduction Breast Cancer Screening and Diagnosis Colorectal Cancer Screening

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Prostate Cancer Early Detection

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Acute Lymphoblastic Leukemia (adult) Acute Lymphoblastic Leukemia in Children Acute Myeloid Leukemia Adolescent and Young Adult Cancer Adrenal Tumors Anal Cancer Anemia and Neutropenia - Low Blood Cell Counts Basal Cell Skin Cancer Bladder Cancer Blood Clots and Cancer Bone Cancer Brain Cancer - Glioma Breast Cancer - Ductal Carcinoma In Situ Breast Cancer - Inflammatory Breast Cancer Breast Cancer - Invasive Breast Cancer Breast Cancer - Metastatic Breast Cancer Breast Cancer Screening and Diagnosis Cervical Cancer Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Colon Cancer Colorectal Cancer Screening Cutaneous B-Cell Lymphomas Cutaneous T-Cell Lymphomas Diffuse Large B-Cell Lymphomas

Distress During Cancer Care Esophageal Cancer Fatigue and Cancer Follicular Lymphoma Gallbladder and Bile Duct Cancers Gastrointestinal Stromal Tumors (GIST) Genetic Testing for Hereditary Breast, Ovarian, Pancreatic, and Prostate Cancers Graft-Versus-Host Disease Hodgkin Lymphoma in Adults Hodgkin Lymphoma in Children Immunotherapy Side Effects: CAR T-Cell Therapy Immunotherapy Side Effects: Immune Checkpoint Inhibitors Kidney Cancer Liver Cancer Lung Cancer Screening Mantle Cell Lymphoma Marginal Zone Lymphomas Melanoma Mouth Cancer Multiple Myeloma Myelodysplastic Syndromes Myeloproliferative Neoplasms Nasopharyngeal Cancer Nausea and Vomiting Neuroendocrine Tumors

Non-Small Cell Lung Cancer - Early and Locally Advanced Non-Small Cell Lung Cancer - Metastatic Ovarian Cancer Palliative Care Pancreatic Cancer Peripheral T-Cell Lymphoma Pleural Mesothelioma Primary Central Nervous System Lymphoma Prostate Cancer: Advanced Stage Prostate Cancer: Early Stage Quitting Smoking Rectal Cancer Small Bowel Adenocarcinoma Small Cell Lung Cancer Soft Tissue Sarcoma Squamous Cell Skin Cancer Stomach Cancer Survivorship Care for Cancer-Related Late and Long-Term Effects Survivorship Care for Healthy Living Systemic Mastocytosis Throat Cancer Thyroid Cancer Uterine Cancer Waldenström Macroglobulinemia

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Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Guidelines

NCCN Guidelines Version 3.2025

- Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

- Histologic Transformation (Richter)

- Histologic Transformation (Richter) and Progression

NCCN Guidelines in Practice™

Earn CME/CE and MOC credits for using the NCCN Guidelines to research your patient care decisions and clinical questions by clicking here.

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NCCN Guidelines with Evidence Blocks Version 3.2025

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Chronic Lymphocytic Leukemia-English Version 2025
Chronic Lymphocytic Leukemia-Spanish Version 2025

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Applying NCCN Guidelines for the Treatment of CLL/SLL in Clinical Practice: The Right Agent for the Right Patient at the Right Time
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Updates in Prognosis and Treatment
An Interactive Case-Based Review of Chronic Lymphocytic Leukemia: Experts Explore the Latest Evidence and Guideline Updates
Expert Perspectives on Updates and Advances in Individualizing CLL/SLL Therapy Across the Disease Course

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Chinese Version 3.2023
Portuguese Version 3.2023
Spanish Version 3.2023
Ukrainian Version 3.2023

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English (Middle East & North Africa) Version 1.2025

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English (Africa) Version 1.2025

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