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NCCN Flash Updates: NCCN Guidelines Updated for Acute Myeloid Leukemia

NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), and the Drugs and Biologics Compendium (NCCN Compendium®) for Acute Myeloid Leukemia. These NCCN Guidelines® are currently available as Version 2.2022.

 Link directly to the Updates section of the NCCN Guidelines: Acute Myeloid Leukemia


  • IDH1 or IDH2 Treatment Induction, preferred regimen added: Ivosidenib once daily (500mg) PO and azacitidine 75 mg/m2 SC or IV (days 1-7 or day 1-5, 8-9 of each 28-day cycle) (category 1) (IDH1 only)


  • Footnote added: This regimen is approved for newly-diagnosed AML with an IDH1 mutation who met at least one of the following criteria: age >75 years, baseline ECOG performance status of ≤ 2, severe cardiac or pulmonary disease, hepatic impairment with bilirubin > 1.5 times the upper limit of normal, creatinine clearance < 45 mL/min, or other comorbidity. Montesinos P, et al. N Engl J Med 2022;386:1519-1531.



For the complete updated versions of the NCCN Guidelines, NCCN Guidelines with NCCN Evidence Blocks™, the NCCN Drugs & Biologics Compendium (NCCN Compendium®), the NCCN Biomarkers Compendium®, the NCCN Chemotherapy Order Templates (NCCN Templates®), the NCCN Radiation Therapy Compendium™, and the NCCN Imaging Appropriate Use Criteria (NCCN Imaging AUC™), please visit NCCN.org.

To view the NCCN Guidelines for Patients®, please visit NCCN.org/patientguidelines.

Free NCCN Guidelines apps for iPhone, iPad, and Android devices are now available! Visit NCCN.org/apps.

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