eBulletin Newsletter

NCCN Flash Updates: NCCN Guidelines Updated for Bladder Cancer

NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) and the NCCN Drugs & Biologics Compendium (NCCN Compendium®) for Bladder Cancer. These NCCN Guidelines® are currently available as Version 4.2024.

Link directly to the Updates section of the NCCN Guidelines: Bladder Cancer


  • High risk, BCG unresponsive, regimen added: Nogapendekin alfa inbakiceptpmln + BCG (select patients)
  • Footnote v added: Nogapendekin alfa inbakicept-pmln in combination with BCG may be considered for the treatment of patients with BCG-unresponsive, high-risk NMIBC with CIS (with or without papillary) tumors.


  • Footnote gg modified: Molecular/genomic testing in a Clinical Laboratory Improvement Amendments (CLIA)-approved laboratory, including FGFR RGQ RT-PCR for FGFR3 genetic alterations and IHC for HER2 overexpression. See Discussion. (Also for BL-9 and BL-10)

BL-G 4 of 7

  • Useful in certain circumstances regimen added: fam-trastuzumab deruxtecan-nxki (HER2-positive, IHC 3+)


  • The discussion section has been updated to reflect the changes in the algorithm.


The NCCN Drugs & Biologics Compendium (NCCN Compendium®) for Head and Neck Cancers has been updated and published based on the most recent changes from the NCCN Guidelines for Head and Neck Cancers v4.2024.



For the complete updated versions of the NCCN Guidelines, NCCN Guidelines with NCCN Evidence Blocks™, the NCCN Drugs & Biologics Compendium (NCCN Compendium®), the NCCN Biomarkers Compendium®, the NCCN Chemotherapy Order Templates (NCCN Templates®), the NCCN Radiation Therapy Compendium™, and the NCCN Imaging Appropriate Use Criteria (NCCN Imaging AUC™), please visit NCCN.org.

To view the NCCN Guidelines for Patients®, please visit NCCN.org/patientguidelines.

Free NCCN Guidelines apps for iPhone, iPad, and Android devices are now available! Visit NCCN.org/apps.

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