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NCCN Flash Updates: NCCN Guidelines Updated for Colon Cancer

NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Colon Cancer. These NCCN Guidelines® are currently available as Version 3.2025.

Link directly to the Updates section of the NCCN Guidelines: Colon Cancer

COL-2

  • Colon cancer appropriate for resection (non-metastatic)
    • Workup recommendation removed: Enterostomal therapist as indicated for preoperative marking of site, teaching
  • Footnote i modified: Testing for DPYD genetic variants should be considered prior to fluoropyrimidine therapy. After discussions regarding risk assessment, patients may choose DPYD genetic testing. However, no specific test is recommended at this time and there are insufficient data to inform dose adjustments for many of the DPYD variants. See Principles of Pharmacogenetics (COL-J) and DPYD Testing and Fluoropyrimidine-Associated Toxicity Discussion section for more information.

COL-J

  • New section added: Principles of Pharmacogenetics

 

 

For the complete updated versions of the NCCN Guidelines, NCCN Guidelines with NCCN Evidence Blocks™, the NCCN Drugs & Biologics Compendium (NCCN Compendium®), the NCCN Biomarkers Compendium®, the NCCN Chemotherapy Order Templates (NCCN Templates®), the NCCN Radiation Therapy Compendium™, and the NCCN Imaging Appropriate Use Criteria (NCCN Imaging AUC™), please visit NCCN.org.

To view the NCCN Guidelines for Patients®, please visit NCCN.org/patientguidelines.

Free NCCN Guidelines apps for iPhone, iPad, and Android devices are now available! Visit NCCN.org/apps.

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