National Comprehensive Cancer Network

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NCCN Guidelines for Treatment of Cancer by Site

NCCN Guidelines for Detection, Prevention, & Risk Reduction

NCCN Guidelines for Supportive Care

NCCN Guidelines for Specific Populations

NCCN Guidelines for Patients

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NCCN GUIDELINES FOR TREATMENT OF CANCER BY SITE

Acute Lymphoblastic Leukemia (Adult and AYA)

Acute Lymphoblastic Leukemia (Pediatric and AYA)

Acute Myeloid Leukemia

Anal Carcinoma

Basal Cell Skin Cancer (See Non-Melanoma Skin Cancers)

Bladder Cancer

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NCCN Guidelines
Bladder Cancer
Upper Tract Tumors
Urothelial Carcinoma of the Prostate
Primary Carcinoma of the Urethra
NCCN Framework for Resource Stratification of NCCN Guidelines (NCCN Framework™)
NCCN Educational Events and Programs
NCCN Guidelines for Patients
NCCN QUICK GUIDE™ sheet for Bladder Cancer
NCCN International Translations/Adaptations

Bone Cancer

NCCN Guidelines with NCCN Evidence Blocks^™ – About NCCN Evidence Blocks^™
NCCN Guidelines
Chondrosarcoma
Chordoma
Ewing's Sarcoma Family of Tumors
Giant Cell Tumor of Bone
Osteosarcoma
NCCN Guidelines for Patients

Breast Cancer

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NCCN Guidelines
Noninvasive
Invasive
Phyllodes Tumor
Paget's Disease
Breast Cancer During Pregnancy
Inflammatory Breast Cancer
NCCN Framework for Resource Stratification of NCCN Guidelines (NCCN Framework™)
- Basic Resources (Preliminary)
- Core Resources (Preliminary)
- Enhanced Resources (Preliminary)
NCCN Guidelines for Patients (Breast Cancer: DCIS)
NCCN Guidelines for Patients (Breast Cancer: Invasive)
NCCN Guidelines for Patients (Breast Cancer: Metastatic)
NCCN QUICK GUIDE™ sheet for Breast Cancer: Invasive
Patient Resources - Know What Your Doctors Know - Breast Cancer: Metastatic
NCCN Educational Events and Programs
NCCN 2020 Congress Series™: Breast Cancer with Updates from 2019 San Antonio Breast Cancer Symposium
NCCN International Translations/Adaptations

Cancer of Unknown Primary (See Occult Primary)

Central Nervous System Cancers

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NCCN Guidelines
Adult Low-Grade (WHO Grade I or II) Glioma/Pilocytic and Infiltrative Supratentorial Astrocytoma/Oligodendroglioma
Anaplastic Gliomas/Glioblastoma
Adult Intracranial Ependymoma
Adult Medulloblastoma
Primary CNS Lymphoma
Primary Spinal Cord Tumors
Meningiomas
Limited Brain Metastases
Extensive Brain Metastases
Leptomeningeal Metastases
Metastatic Spine Tumors
NCCN Guidelines for Patients for Brain Cancer/Gliomas
NCCN Guidelines for Patients for Primary Central Nervous System Lymphoma
NCCN Educational Events and Programs

Cervical Cancer

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Chronic Myeloid Leukemia

Colon Cancer

Cutaneous Melanoma (See Melanoma)

Dermatofibrosarcoma Protuberans (See Non-Melanoma Skin Cancers)

Endometrial Cancer (See Uterine Neoplasms)

Esophageal and Esophagogastric Junction Cancers

Fallopian Tube Cancer (See Ovarian Cancer)

Gastric Cancer

Gastrointestinal Stromal Tumors (GIST)

Gestational Trophoblastic Neoplasia

Hairy Cell Leukemia

Head and Neck Cancers

NCCN Guidelines with NCCN Evidence Blocks^™ – Very Advanced Head and Neck Cancer – About NCCN Evidence Blocks^™
NCCN Guidelines
Cancer of the Lip
Cancer of the Oral Cavity
Cancer of the Oropharynx
Cancer of the Hypopharynx
Cancer of the Nasopharynx
Cancer of the Glottic Larynx
Cancer of the Supraglottic Larynx
Ethmoid Sinus Tumors
Maxillary Sinus Tumors
Very Advanced Head and Neck Cancers
Occult Primary
Salivary Gland Tumors
Mucosal Melanoma
NCCN Framework for Resource Stratification of NCCN Guidelines (NCCN Framework™) – Cancers of the Lip and Oral Cavity
- Basic Resources
- Core Resources
- Enhanced Resources
NCCN Guidelines for Patients for Oral Cancers
NCCN Guidelines for Patients for Nasopharyngeal Cancer
NCCN Guidelines for Patients for Oropharyngeal Cancer
NCCN QUICK GUIDE™ sheet for Oral Cancers
NCCN QUICK GUIDE™ sheet for Nasopharyngeal Cancer
NCCN Educational Events and Programs

Hepatobiliary Cancers

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NCCN Guidelines
Hepatocellular Carcinoma
Biliary Tract Cancers

Gallbladder Cancer
Intrahepatic Cholangiocarcinoma
Extrahepatic Cholangiocarcinoma

NCCN Framework for Resource Stratification of NCCN Guidelines (NCCN Framework™) – Hepatocellular Carcinoma and Gallbladder Cancer
NCCN Guidelines for Patients for Gallbladder and Bile Duct Cancers
NCCN QUICK GUIDE™ for Gallbladder and Bile Duct Cancers
NCCN Guidelines for Patients for Liver Cancer
NCCN QUICK GUIDE™ for Liver Cancer
NCCN Educational Events and Programs
NCCN International Translations/Adaptations

Hodgkin Lymphoma (Adult and AYA)

Hodgkin Lymphoma (Pediatric and AYA)

Kaposi Sarcoma

Kidney Cancer

Malignant Pleural Mesothelioma

Melanoma

Melanoma: Cutaneous

Melanoma: Uveal

Merkel Cell Carcinoma (See Non-Melanoma Skin Cancers)

Multiple Myeloma/Other Plasma Cell Neoplasms

Multiple Myeloma

Systemic Light Chain Amyloidosis

Waldenström Macroglobulinemia / Lymphoplasmacytic Lymphoma

Myelodysplastic Syndromes

Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) (See Myelodysplastic Syndromes)

Myeloid/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Fusion Genes

Myeloproliferative Neoplasms

NCCN Guidelines with NCCN Evidence Blocks^™ – About NCCN Evidence Blocks^™
NCCN Guidelines
Myelofibrosis
Polycythemia Vera
Essential Thrombocythemia
NCCN Guidelines for Patients
NCCN QUICK GUIDE™ sheet for Myeloproliferative Neoplasms
Patient Resources - Know What Your Doctors Know: Myeloproliferative Neoplasms (MPN)

Neuroendocrine and Adrenal Tumors

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NCCN Guidelines
Neuroendocrine Tumors of the GI, Lung and Thymus (Carcinoid Tumors)
Neuroendocrine Tumors of the Pancreas
Neuroendocrine Unknown Primary
Adrenal Gland Tumors
Pheochromocytoma/Paraganglioma
Poorly Differentiated (High Grade or Anaplastic)/Small Cell
Multiple Endocrine Neoplasia, Type 1
Multiple Endocrine Neoplasia, Type 2
NCCN Guidelines for Patients
NCCN QUICK GUIDE™
NCCN Educational Events and Programs

Non-Hodgkin Lymphomas

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (See Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma)

B-Cell Lymphomas

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NCCN Guidelines
Follicular Lymphoma
Marginal Zone Lymphomas

Gastric MALT Lymphoma
Nongastric MALT Lymphoma
Nodal Marginal Zone Lymphoma
Splenic Marginal Zone Lymphoma

Mantle Cell Lymphoma
Diffuse Large B-Cell Lymphoma
High-Grade B-Cell Lymphomas

High-Grade B-Cell Lymphomas with Translocations of MYC and BCL2 and/or BCL6 (Double/Triple Hit Lymphoma)
High-Grade B-Cell Lymphomas, NOS

Burkitt Lymphoma
AIDS-Related B-Cell Lymphomas
Lymphoblastic Lymphoma
Post-Transplant Lymphoproliferative Disorders
Castleman Disease
NCCN Framework for Resource Stratification of NCCN Guidelines (NCCN Framework™) – Diffuse Large B-cell Lymphoma and Burkitt Lymphoma
- Basic Resources
- Core Resources
- Enhanced Resources
NCCN Guidelines for Patients - Diffuse Large B-Cell Lymphoma
NCCN Guidelines for Patients - Follicular Lymphoma
NCCN Guidelines for Patients - Mantle Cell Lymphoma
NCCN QUICK GUIDE™ sheet for Diffuse Large B-Cell Lymphoma
NCCN QUICK GUIDE™ sheet for Follicular Lymphoma
NCCN QUICK GUIDE™ sheet for Mantle Cell Lymphoma
NCCN Educational Events and Programs
NCCN International Translations/Adaptations

Hairy Cell Leukemia (See Hairy Cell Leukemia)

Pediatric Aggressive Mature B-Cell Lymphomas

NCCN Guidelines with NCCN Evidence Blocks^™ – About NCCN Evidence Blocks^™
NCCN Guidelines
Burkitt Lymphoma
Diffuse Large B-Cell Lymphoma

Primary Cutaneous Lymphomas

NCCN Guidelines with NCCN Evidence Blocks^™ – About NCCN Evidence Blocks^™
NCCN Guidelines
Primary Cutaneous B-Cell Lymphomas
Mycosis Fungoides/Sézary Syndrome
Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorders
NCCN Educational Events and Programs
NCCN International Translations/Adaptations

T-Cell Lymphomas

NCCN Guidelines with NCCN Evidence Blocks^™ – About NCCN Evidence Blocks^™
NCCN Guidelines
Peripheral T-Cell Lymphoma, Noncutaneous
Breast Implant-Associated Anaplastic Large Cell Lymphoma (ALCL)
T-cell Large Granular Lymphocytic Leukemia
Adult T-Cell Leukemia/Lymphoma
T-Cell Prolymphocytic Leukemia
Extranodal NK/T-Cell Lymphoma, nasal type
Hepatosplenic Gamma-Delta T-cell Lymphoma
NCCN Guidelines for Patients - Mycosis Fungoides
NCCN Guidelines for Patients - Peripheral T-cell Lymphoma
NCCN QUICK GUIDE™ sheet for Mycosis Fungoides
NCCN QUICK GUIDE™ sheet for Peripheral T-cell Lymphoma
NCCN Educational Events and Programs
NCCN International Translations/Adaptations

Non-Melanoma Skin Cancers

Basal Cell Skin Cancer

Dermatofibrosarcoma Protuberans

Merkel Cell Carcinoma

Squamous Cell Skin Cancer

Non-Small Cell Lung Cancer

Occult Primary

Ovarian Cancer

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NCCN Guidelines
Epithelial Ovarian Cancer (including Fallopian Tube Cancer and Primary Peritoneal Cancer)
Borderline Epithelial Ovarian Cancer (Low Malignant Potential)
Less Common Ovarian Histologies
NCCN Guidelines for Patients
NCCN QUICK GUIDE™ for Ovarian Cancer
NCCN Educational Events and Programs
NCCN International Translations/Adaptations

Pancreatic Adenocarcinoma

Penile Cancer

Primary Peritoneal Cancer (See Ovarian Cancer)

Prostate Cancer

Rectal Cancer

Small Bowel Adenocarcinoma

Small Cell Lung Cancer

Soft Tissue Sarcoma

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NCCN Guidelines
Extremity
Retroperitoneal/Intra-Abdominal
Gastrointestinal Stromal Tumors (GIST) (See Gastrointestinal Stromal Tumors (GIST))
Desmoid Tumors
Rhabdomyosarcoma
NCCN Guidelines for Patients
NCCN Educational Events and Programs

Squamous Cell Skin Cancer (See Non-Melanoma Skin Cancers)

Systemic Mastocytosis

Testicular Cancer

Thymomas and Thymic Carcinomas

Thyroid Carcinoma

NCCN Guidelines with NCCN Evidence Blocks^™ – About NCCN Evidence Blocks^™
NCCN Guidelines
Nodule Evaluation
Papillary Carcinoma
Follicular Carcinoma
Hürthle Cell Neoplasm
Medullary Carcinoma
Anaplastic Carcinoma
NCCN Guidelines for Patients

Uterine Neoplasms

Vulvar Cancer

Wilms Tumor (Nephroblastoma)

NCCN Guidelines

NCCN GUIDELINES FOR DETECTION, PREVENTION, & RISK REDUCTION

Breast Cancer Risk Reduction

Breast Cancer Screening and Diagnosis

NCCN Guidelines
NCCN Framework for Resource Stratification of NCCN Guidelines (NCCN Framework™)
- Basic Resources (Preliminary)
- Core Resources (Preliminary)
- Enhanced Resources (Preliminary)

Cervical Cancer Screening

The NCCN Guidelines Panel for Cervical Cancer Screening endorses the following guidelines:

For the prevention and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. Am J Clin Pathol 2012;137:516-542. Available at: https://doi.org/10.1309/AJCPTGD94EVRSJCG
For the management of abnormal cervical screening tests and cancer precursors: 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. J Low Genit Tract Dis 2013;17(5 Suppl 1):S1-S27. Available at: http://www.asccp.org/

Colorectal Cancer Screening

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic

NCCN Guidelines
High-Penetrance Breast and Ovarian Cancer Susceptibility Genes
Pancreatic Cancer Susceptibility Genes
Li-Fraumeni Syndrome
Cowden Syndrome/PTEN Hamartoma Tumor Syndrome
NCCN International Translations/Adaptations

Genetic/Familial High-Risk Assessment: Colorectal

NCCN Guidelines

Lung Cancer Screening

Prostate Cancer Early Detection

NCCN GUIDELINES FOR SUPPORTIVE CARE

Adult Cancer Pain

Antiemesis

NCCN Guidelines

Cancer- and Chemotherapy-Induced Anemia (See Hematopoietic Growth Factors)

Cancer-Associated Venous Thromboembolic Disease

NCCN Guidelines

Cancer-Related Fatigue

NCCN Guidelines

Distress Management

Hematopoietic Cell Transplantation

NCCN Guidelines
Pre-Transplant Recipient Evaluation
Management of Graft-Versus-Host Disease

Hematopoietic Growth Factors

NCCN Guidelines
Management of Cancer- and Chemotherapy-Induced Anemia
Management of Neutropenia

Management of Immunotherapy-Related Toxicities

NCCN Guidelines
Immune Checkpoint-Inhibitor Toxicities
CAR T-Cell-Related Toxicities
NCCN Guidelines for Patients - Immunotherapy Side Effects: CAR T-Cell Therapy
NCCN QUICK GUIDE™ sheet for Immunotherapy Side Effects: CAR T-Cell Therapy
NCCN Guidelines for Patients - Immunotherapy Side Effects: Immune Checkpoint Inhibitors
NCCN QUICK GUIDE™ sheet for Immunotherapy Side Effects: Immune Checkpoint Inhibitors

Myeloid Growth Factors (See Hematopoietic Growth Factors)

Palliative Care

Prevention and Treatment of Cancer-Related Infections

NCCN Guidelines

Smoking Cessation

NCCN Guidelines

Survivorship

NCCN Guidelines
Preventive Health

Healthy Lifestyles

Physical Activity
Nutrition and Weight Management
Supplement Use

Immunizations and Infections

Late Effects/Long-Term Psychosocial and Physical Problems
- Anthracycline-Induced Cardiac Toxicity
- Anxiety and Depression
- Cognitive Function
- Fatigue
- Lymphedema
- Menopause-Related Symptoms
- Pain
- Sexual Function (female/male)
- Sleep Disorders
NCCN Guidelines for Patients for Survivorship Care for Cancer-Related Late and Long-Term Effects
NCCN Guidelines for Patients for Survivorship Care for Healthy Living

NCCN GUIDELINES FOR SPECIFIC POPULATIONS

Adolescent and Young Adult (AYA) Oncology

Cancer in People with HIV

NCCN Guidelines

Older Adult Oncology

NCCN Guidelines

Disclaimer
The NCCN Guidelines are a statement of consensus of the authors regarding their views of currently accepted approaches to cancer treatment. The recommendations regarding the uses and indications in the NCCN Compendium have been derived directly from the NCCN Guidelines. The NCCN Compendium represents neither an all-inclusive listing of every drug and biologic nor every appropriate use and indication for drugs and biologics. The NCCN Templates are peer reviewed statements of consensus of their authors derived from the NCCN Guidelines for the conditions the NCCN Templates address. The NCCN Templates are not exhaustive and do not represent the full spectrum of care or treatment options described in the NCCN Guidelines or the NCCN Compendium or include all appropriate approaches or combinations of drugs or biologics for the treatment of cancer. A NCCN Template does not constitute an order.

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